Microfluidics Product Portfolio

Main features of the chip:

The chip consists of two concentric chambers, the microfluidic channel, stretchable microelectrodes, gel filling ports, channel inlet/outlet, and contact pads. The central chamber (CC) and the peripheral chamber (PC) are separated by the microfluidic channel. The chambers are loaded with a suspension of the cells (neurons, glia) in Matrigel or another hydrogel through the gel filling ports (CC Port, PC Port 1, 2 , 3). The chambers are perfused with medium and drugs through the channel inlet and outlet. The stretchable electrodes enable recording and stimulation of electrophysiological activity in the 3D culture. The electrical connection with the data acquisition system is made via contact contact pads on the chip and pogo pins on the interface board.

34mMEA-200-960-4iR-Au-1W

Single-Well: Stretchable with Electrophysiology

Design

• Incorporates stretchable electrodes into the dual-chamber format (same as 3D-SW).

Features

• In-situ, real-time electrophysiological recordings

• Bio-mechanical stimulation capabilities (simulate TBI conditions)

• Supports both neuron monocultures and neuron–glia co-cultures

Application

• Functional assessment of neuronal health before and after mechanical injury

View Technical Specifications

Product Number (PN): 11-54110

0mSW-0-0-0iR-1W

Single-Well: Stretchable without Electrophysiology

Design

• Concentric chambers separated by a microfluidic channel.

Features

• Nutrient and drug delivery

• Integrated imaging and mechanical stretching

• Ideal for baseline 3D cell cultures and drug screening assays

Application

• Modeling AD pathology and other neurological and neurogenerative diseases

View Technical Specifications

Product Number (PN): 11-55210

20mMEA-120-400-2iR-Au-6W

Six-Well: Stretchable with Electrophysiology

Design

• Multi-well configuration for experiments that require electrophysiological readouts.

Features

• Six individual wells with integrated dual-chamber design and stretchable electrodes

• Enables parallel experiments, essential for drug screening and comparative studies

Application

• High-throughput screening for drug efficacy and toxicity in AD/ADRD models.

Product Number (PN): 11-52310

0mSW-0-0-0iR-6W

Six-Well: Stretchable without Electrophysiology

Design

• Multi-well configuration for experiments not requiring electrophysiological readouts.

Features

• Simplified design focused on imaging, nutrient delivery, and mechanical deformation

• Cost-effective option for studies where electrical recordings are secondary

Application

• Broad applications in cell viability and morphological studies.

Product Number (PN): 11-55220

Perfusion Module

Overview

• The microfluidic chip can be readily interfaced with the perfusion system of your choice via BMSEED’s connector which is the interface between the microfluidic chip and the perfusion hardware. The connector allows to reliably connect the microfluidic channel on the chip with the perfusion hardware without introducing air bubbles. The choice of perfusion system depends on the required accuracy of flow. An inexpensive syringe pump can be used for applications that do not require high accuracy of flow rates. For higher accuracy, BMSEED can recommend available options.

Features (In Development)

• Automated, precise control of fluid flow rates (1–80 µL/min) with compression seal

• Integration with single-well and multi-well systems

• Compatibility with real-time imaging and electrophysiological recording setups

Benefits

• Ensures consistent delivery of nutrients, pharmacological agents, and biomarkers, critical for replicating in vivo-like microenvironments.