In Vitro Research Tools with In Vivo Relevance

BMSEED bridges the gap between the lab and the human body with dynamic 3D platforms that combine biomechanics and electrophysiology to replicate real physiological environments.

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MEASSuRE-Premium cell stretcher

MEASSuRE: 3 methods, 1 tool

MEASSuRE is a complete solution for researchers to stretch cells/tissue mechanically, image them optically, and record/stimulate electrophysiological activity, independently or concurrently

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stretchable microelectrode array

Stretchable MultiElectrode Array

Stretchable MultiElectrode Arrays are used in the MEASSuRE system. They provide the only method for researchers to manipulate chemical, electrical, & mechanical factors independently to better replicate the complexity of the human body.

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What Our Customers Say

Our systems deliver precise mechanical and electrical control for reproducible, quantifiable data, improving preclinical predictivity and advancing the translational power of in vitro research.

“Easiness for acquiring electrical signal in a non-invasive manner.”

-A. Patino, Ph.D. Arizona State University

“The most valuable thing is that we can record from cells multiple times…injure and record on the same device.”

-M.K. Dwyer, M.S. Columbia University

“Tuneable parameters and very fast to use.”

-A. Pybus, Ph.D. Georgia Institute of Technology

About Us

cell and tissue culture on stretchable microelectrode arrays

a) organotypic hippocampal slice cultures (OHSCs), long-term potentiation (LTD) & long-term depression (LTD) induced post-injury; b) primary hippocampal neurons (PHNs) & brain tissue tolerance to traumatic brain injury (TBI); c) organotypic spinal cord slice cultures (OSCSCs) & cypin regulated pain sensitivity after spinal cord injury (SCI); d) human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), hiPSC-CM differentiation; e) neurons, astrocytes, & microglia, pro-inflammatory signaling & immune response to mild traumatic brain injury (mTBI)

Accurate Data

Simulate the cell’s natural environment in the body to generate more relevant in vitro data.

Efficient Workflow

Concurrently apply multiple paradigms with MEASSuRE to save time, money, and research animals.

Unrivaled Results

Better predict clinical outcomes by eliminating drug candidates early & reduce failure rate in clinical trials.

Latest Publications

Long-term potentiation and long-term depression are both impaired after in vitro stretch injury measured with stretchable microelectrode arrays

M. K. Dwyer, I. Polsfuss, K. Herbert, N. Varghese, B. Morrison III

Biomedical Physics & Engineering Express, 2025, 11(2025)045029

NTS-105 decreased cell death and preserved long-term potentiation in an in vitro model of moderate traumatic brain injury

M. K. Dwyer, N. Amelinez-Robles, I. Polsfuss, K. Herbert, C. Kim, N. Varghese, T. J. Parry, B. Buller, T. A. Verdoorn, C. B. Billing Jr, B. Morrison III

Experimental Neurology, 2024, 371, 114608

Organotypic hippocampal slice culture on stretchable microelectrode array, TBI model

Stretch‑Induced Injury Affects Cortical Neuronal Networks in a Time‑ and Severity‑Dependent Manner

D. Sullivan, B. J. Vaglio, M. M. Cararo‑Lopes, R. D. Ponce Wong, O. Graudejus, B. L. Firestein

Annals of Biomedical Engineering, 2024, 52(4), 1021-1038

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Integrate Cellular Biomechanics with Electrophysiology to Better Predict In Vivo Behavior

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stretchable MEA before and during stretch